Enhanced Treatment in Severe-Critical COVID-19 With Tocilizumab, Remdesivir, Dexamethasone: A Jordanian Cohort Study

• Published in: Curēus (Palo Alto, CA) Vol. 16; no. 8; p. e67467
• Main Authors: Al-Mistarehi, Abdel-Hameed W, El-Akawi, Shadi, Kheirallah, Khalid A, Bani Ata, Ehab M, Zaitoun, Khaled J, Khassawneh, Ahmad B, Jarrah, Abdullah, Alzoubi, Hamed M, Al-Azzam, Sayer, Karasneh, Reema A, Altawalbeh, Rana B, Khassawneh, Basheer
• Format: Journal Article
• Language: English
• Published: United States Cureus Inc 22-08-2024; Cureus
• Subjects: Antiviral drugs; COVID-19; Drug dosages; Infectious Disease; Monoclonal antibodies; Mortality; Pulmonology; Therapeutics; Viral infections; dexamethasone; tocilizumab; treatment outcomes; remdesivir; covid-19 therapy
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.67467

Several medications have been proposed to manage COVID-19, with controversial data regarding their clinical benefits. We aimed to investigate the clinical efficacy of using remdesivir (RDV) with and without tocilizumab (TCZ) and standard therapy in treating severe COVID-19.
This retrospective cohort study was conducted in a Jordanian tertiary hospital (September 26th, 2020 - August 28th, 2021) and included adult COVID-19 patients requiring oxygen support. Patients were categorized into three groups based on treatment: TCZ+RDV and standard therapy; RDV and standard therapy; and standard therapy alone, which included dexamethasone, vitamins, anticoagulants, and ceftriaxone.
Of 1,556 screened, 1,244 patients (mean age 62.33, 60.8% men) were included. Distribution was 106 in TCZ+RDV, 520 in RDV, and 618 in standard therapy. No significant differences were observed in age, gender, or BMI. Mortality was lowest in TCZ+RDV (32.1%), followed by RDV (40.6%) and standard therapy (47.1%) (p=0.005). Among ICU patients, TCZ+RDV showed significantly lower mortality (51.1%) compared to RDV (75%) and standard therapy (85.8%) (p<0.001). The ICU stays and invasive mandatory ventilation (IMV) durations were significantly shorter with TCZ+RDV (4.30 and 2.69 days, respectively) compared to RDV (7.61 and 4.52 days) and standard therapy (7.98 and 5.32 days) (p<0.001 for ICU stays, p=0.025 for IMV durations).
Combining TCZ, RDV, and dexamethasone shows promise in reducing mortality and ICU/IMV duration for severe COVID-19.