Renoprotective effects of Silybum marianum (L.) Gaertn (Silymarin) on thioacetamide-induced renal injury: Biochemical and histopathological approach

• Published in: Pakistan journal of pharmaceutical sciences Vol. 31; no. 5(Supplementary); p. 2137
• Main Author: Cengiz, Mustafa Z
• Format: Journal Article
• Language: English
• Published: Pakistan 01-09-2018
• Subjects: Acute Kidney Injury - chemically induced; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Acute Kidney Injury - prevention & control; Animals; Antioxidants - isolation & purification; Antioxidants - therapeutic use; Male; Protective Agents - isolation & purification; Protective Agents - therapeutic use; Rats; Rats, Wistar; Silybum marianum; Silymarin - isolation & purification; Silymarin - therapeutic use; Thioacetamide - toxicity
• ISSN: 1011-601X

Thioacetamide (TAA), recognized as an experimental toxin, mainly causes acute liver damage through the production of free radicals. TAA as well induces renal dysfunction hence; renal failure is often related with the end-stage of the hepatic damage. The aim of the current study was to examine the protective effects of Silymarin (Sil) against TAA-induced kidney damage in this current study. The twenty eight rats were separated into four groups. Group 1 was performed as control (saline 0,5 mL intraperitonally i.p.). Group 2 was given to 50 mg/kg TAA (i.p.). Group 3 was administrated with TAA just after 50 mg/kg Sil (per os (p.o.)). Group 4 was treated to TAA just after 100 mg/kg Sil. In end (fourteenth days) of study, tissue and blood samples of animals were collected for morphological and biochemical assessment. Our results show that Sil treatment apart from the TAA administration profitably changed the poisonous effects on the rats. In addition, 100 mg/kg Sil was more protective than 50 mg/kg Sil treatment indicated by histopathological, and biochemical values. In conclusion, Sil therapy before TAA could guard kidney tissues against TAA induced nephrotoxicity.