Risk factors for the appearance of secondary foci of infection in children with community-acquired Staphylococcus aureus bacteraemia. Cohort study 2010-2016

• Published in: Enfermedades infecciosas y microbiologia clinica Vol. 36; no. 8; pp. 493 - 497
• Main Authors: Perez, M Guadalupe, Martiren, Soledad, Escarra, Florencia, Reijtman, Vanesa, Mastroianni, Alejandra, Varela-Baino, Ana, Cedillo, Carola, Garcia, M Eva, Taicz, Moira, Bologna, Rosa
• Format: Journal Article
• Language: English; Spanish
• Published: Spain 01-10-2018
• Subjects: Adolescent; Bacteremia - epidemiology; Child; Child, Preschool; Cohort Studies; Coinfection - epidemiology; Community-Acquired Infections - epidemiology; Female; Humans; Infant; Male; Risk Factors; Spain - epidemiology; Staphylococcal Infections - epidemiology; Time Factors; Spain; Staphylococcus aureus comunitario; Niños; Children; Community-acquired Staphylococcus aureus; Focos secundarios; Secondary foci; Staphylococcus aureus
• ISSN: 1578-1852; 2529-993X
• DOI: 10.1016/j.eimc.2017.10.007

Community-acquired Staphylococcus aureus (SA) bacteraemia is a common cause of hospitalisation in children. The occurrence of secondary foci (SF) of SA infection is associated with higher morbidity and mortality.
To identify risk factors for SF of infection in children with community-acquired SA bacteraemia.
Prospective cohort. All children aged from 30 days to 16 years admitted to a paediatric referral hospital between January 2010 and December 2016 for community-acquired infections, with SA isolated in blood cultures, were included. Microbiological, demographic and clinical characteristics were compared, with or without SF infection after 72hours of hospitalisation.
A total of 283 patients were included, 65% male (n=184), with a median age of 60 months (IQR: 30-132). Seventeen per cent (n=48) had at least one underlying disease and 97% (n=275) had some clinical focus of infection, the most common being: osteoarticular 55% (n=156) and soft tissue abscesses 27% (n=79). A total of 65% (n=185) were resistant to methicillin. A SF of infection was found in 16% of patients (n=44). The SF identified were pneumonia 73% (n=32), osteoarticular 11% (n=5), soft tissue 11% (n=5) and central nervous system 5% (n=2). In the multivariate analysis, the persistence of positive blood cultures after the fifth day (OR: 2.40, 95%CI: 1.07-5.37, P<0.001) and sepsis (OR: 17.23, 95%CI 5.21-56.9, P<0.001) were predictors of SF. There was no association with methicillin sensitivity.
In this cohort, methicillin-resistant SA infections predominated. The occurrence of SF of infection was associated with the persistence of bacteraemia after the fifth day and sepsis on admission.