Oncogenic osteomalacia induced by a sinonasal tumour: case report and review

Oncogenic osteomalacia (OOM) is a rare paraneoplastic syndrome characterized by hypophosphatemia and overexpression of a phosphaturic agent, fibroblast growth factor 23 (FGF23). OOM is associated with a variety of mesenchymal tumours referred to as phosphaturic mesenchymal tumours. Head and neck reg...

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Bibliographic Details
Published in:	B-ENT (Leuven) Vol. 10; no. 2; p. 149
Main Authors:	Kabtouri, H, Karmali, R, Spinato, L, Khamaktchian, M, Bisschop, P
Format:	Journal Article
Language:	English
Published:	Belgium 2014
Subjects:	Adult Ethmoid Sinus Female Hemangiopericytoma - complications Humans Neoplasms, Connective Tissue - etiology Paranasal Sinus Neoplasms - complications Paraneoplastic Syndromes - complications
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Summary:	Oncogenic osteomalacia (OOM) is a rare paraneoplastic syndrome characterized by hypophosphatemia and overexpression of a phosphaturic agent, fibroblast growth factor 23 (FGF23). OOM is associated with a variety of mesenchymal tumours referred to as phosphaturic mesenchymal tumours. Head and neck regions are concerned in 5-10% of cases. We report the case of a 42-year-old female with OOM caused by a hemangiopericytoma of the left ethmoid sinus. The period between first symptoms and surgical excision of the lesion was approximately 5 years. We also conducted a PubMed-based search to identify all cases of OOM related to sinonasal tumour. Twenty eight cases in the sinonasal area were reported in the literature. OOM is an important diagnosis because resection of the causative tumour results in cure of the disease.
ISSN:	1781-782X