Synchronous quadruple primary tumors of thyroid, breast, pancreas, and stomach: a case report

• Published in: Anticancer research Vol. 33; no. 5; pp. 2135 - 2138
• Main Authors: Kim, Jong-Sun, Chung, Cho-Yun, Park, Hyung-Chul, Myung, Dae-Seong, Cho, Sung-Bum, Lee, Wan-Sik, Min, Jung-Joon, Joo, Young-Eun
• Format: Journal Article
• Language: English
• Published: Greece 01-05-2013
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - drug therapy; Aged; Biopsy, Fine-Needle; Breast Neoplasms - diagnosis; Breast Neoplasms - drug therapy; Carcinoma, Papillary - diagnosis; Carcinoma, Papillary - drug therapy; Female; Fluorodeoxyglucose F18; Humans; Neoplasm Staging; Neoplasms, Multiple Primary - diagnosis; Neoplasms, Multiple Primary - drug therapy; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - drug therapy; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Stomach Neoplasms - diagnosis; Stomach Neoplasms - drug therapy; Thyroid Neoplasms - diagnosis; Thyroid Neoplasms - drug therapy; Tomography, X-Ray Computed; stomach; Synchronous cancer; thyroid; breast; pancreas
• ISSN: 1791-7530

We herein present the first case to be reported of synchronous quadruple primary cancer of the thyroid, breast, pancreas and stomach in a 70-year-old female. Fluorine-18-fluorodeoxyglucose (FDG)-positron-emission tomography/computed tomography (PET/CT) revealed increased FDG activity in the thyroid, left breast, pancreatic body and antrum of the stomach. To make a definitive diagnosis of synchronous quadruple primary tumors, ultrasound-guided fine-needle aspiration (FNA) cytology and biopsy of the thyroid, breast, pancreas and stomach were performed. FNA cytology and biopsy findings showed papillary carcinoma of the thyroid, invasive ductal adenocarcinoma of the breast, adenocarcinoma of the pancreas and gastrointestinal stromal tumor. To the best of our knowledge, this combination of synchronous multiple primary tumors has not been reported.