Brain abscess caused by Haemophilus influenzae type E in a pediatric patient suffering from Apert syndrome

• Published in: Revista argentina de microbiología Vol. 46; no. 4; pp. 298 - 301
• Main Authors: Isasmendi, Adela M, Pinheiro, José L, Escudé, Natalia García, Efrón, Adriana M, Moscoloni, María A, Hernández, Claudia M
• Format: Journal Article
• Language: Spanish
• Published: Argentina 01-10-2014
• Subjects: Acrocephalosyndactylia; Brain Abscess - microbiology; Child; Haemophilus Infections - complications; Haemophilus influenzae; Humans; Male; Brain abscess; Síndrome de Aper; Apert syndrome; Absceso cerebral; Haemophilus influenzae
• ISSN: 0325-7541
• DOI: 10.1016/S0325-7541(14)70085-9

We report a case of a brain abscess caused by Haemophilus influenzae type e in a 12 year-old patient suffering from Apert syndrome. Apert syndrome is characterized by the premature closure of cranial sutures. In 2010 the patient suffered head trauma in the frontal area with cranial fracture and a cerebrospinal fluid fistula. In February 2013 he was admitted to hospital with fever, vomiting and generalized tonic-clonic seizure with deteriorating mental status/progressive sensory impairment. The computerized axial tomographic scan showed a right frontal lesion, perilesional edema, mild ventricular dilatation and pansinusitis. A brain abscess was diagnosed and drained. The clinical sample was then cultured. A gram negative coccobacillus was isolated and identified as Haemophilus influenzae serotype e. Empirical treatment was started with meropenem (120 mg/kg/day) and vancomycin (60 mg/kg/day), which was later switched to ceftriaxone (100 mg/kg/day) and metronidazole (500 mg/8 h) after culture results arrived. The patient was discharged in good clinical condition.