Submammary Granular Parakeratosis Treated With Mastopexy

Granular parakeratosis, originally named axillary granular parakeratosis, is an uncommon disease with an unclear etiology. It is thought to result from defective processing of profillagrin to fillagrin, causing retention of keratohyaline granules in the epidermis. A myriad of causative factors has b...

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Bibliographic Details
Published in:	Journal of drugs in dermatology Vol. 16; no. 8; p. 810
Main Authors:	Nelson, Garrett, Lien, Mary H, Messina, Jane L, Ranjit, Sonali, Fenske, Neil Alan
Format:	Journal Article
Language:	English
Published:	United States 01-08-2017
Subjects:	Adult Axilla Diagnosis, Differential Female Humans Parakeratosis - diagnosis Parakeratosis - surgery
Online Access:	Get more information
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Summary:	Granular parakeratosis, originally named axillary granular parakeratosis, is an uncommon disease with an unclear etiology. It is thought to result from defective processing of profillagrin to fillagrin, causing retention of keratohyaline granules in the epidermis. A myriad of causative factors has been proposed, including friction, moisture, heat, and contact irritants such as deodorants. We present a case in the inframammary area that resolved with mastopexy, further supporting the role of friction, moisture, and heat. Furthermore, we present electron microscopic evidence demonstrating non-degraded keratohyaline granules upon epidermal maturation. This entity, we believe, is reactive and represents a protective response of the body to moisture and heat. J Drugs Dermatol. 2017;16(8):810-812..
ISSN:	1545-9616