Ticagrelor-induced renal failure leading to statin-induced rhabdomyolysis

Renal function deterioration is a rather frequent side effect of ticagrelor; this is especially so in patients over the age of 75, with pre-existent mild renal failure and/or taking an angiotensin receptor inhibitor. We describe a patient in whom deterioration of renal function due to ticagrelor led...

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Bibliographic Details
Published in:	Netherlands journal of medicine Vol. 73; no. 3; pp. 136 - 138
Main Authors:	van Vuren, A J, de Jong, B, Bootsma, H P R, Van der Veen, M J, Feith, G W
Format:	Journal Article
Language:	English
Published:	Netherlands 01-03-2015
Subjects:	Acute Kidney Injury - chemically induced Adenosine - adverse effects Adenosine - analogs & derivatives Aged Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Male Rhabdomyolysis - etiology Rosuvastatin Calcium - adverse effects
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Summary:	Renal function deterioration is a rather frequent side effect of ticagrelor; this is especially so in patients over the age of 75, with pre-existent mild renal failure and/or taking an angiotensin receptor inhibitor. We describe a patient in whom deterioration of renal function due to ticagrelor led to a rise in serum concentration of rosuvastatin which resulted in rhabdomyolysis. The presented case emphasises the importance to check renal function routinely before and one month after starting ticagrelor and to screen carefully for possible interactions with other drugs.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1872-9061