Curcumin for the Treatment of Glioblastoma

Glioblastoma multiforme is a highly aggressive primary cancer of the brain associated with a poor prognosis. Modest increases in survival can sometimes be achieved with the use of temozolomide and radiation therapy after surgery, but second-line therapy after recurrence has a limited efficacy. Curcu...

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Bibliographic Details
Published in:	Anticancer research Vol. 35; no. 12; pp. 6373 - 6378
Main Authors:	Sordillo, Laura A, Sordillo, Peter P, Helson, Lawrence
Format:	Journal Article
Language:	English
Published:	Greece 01-12-2015
Subjects:	Blood-Brain Barrier Curcumin - administration & dosage Curcumin - pharmacology Curcumin - therapeutic use Drug Therapy, Combination - methods Glioblastoma - drug therapy Glioblastoma - mortality Humans Prognosis Survival Rate lipophilic agent ceramide blood–brain barrier review Glioblastoma combination chemotherapy cancer stem cells lomustine curcumin
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Summary:	Glioblastoma multiforme is a highly aggressive primary cancer of the brain associated with a poor prognosis. Modest increases in survival can sometimes be achieved with the use of temozolomide and radiation therapy after surgery, but second-line therapy after recurrence has a limited efficacy. Curcumin has demonstrated promising results against this form of cancer in experimental models. The reported activity of curcumin against cancer stem cells, a major cause of glioblastoma resistance to therapy, and its ability to augment the apoptotic effects of ceramides, suggest it would have a synergistic effect with cytotoxic chemotherapy agents currently used in second-line therapy, such as lomustine.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1791-7530