Bacterobilia in acute cholecystitis: Bile cultures' isolates, antibiotic sensitivities and antibiotic usage. A study on a Pakistani population

• Published in: Journal of the Pakistan Medical Association Vol. 66(Suppl 3); no. 10; pp. S50 - S52
• Main Authors: Hadi, Yousaf Bashir, Waqas, Muhammad, Umer, Hafiz Muhammad, Alam, Ammar, Alvi, Abdul Rehman, Khan, Muhammad Rizwan
• Format: Journal Article
• Language: English
• Published: Pakistan 01-10-2016
• Subjects: Adult; Aged; Anti-Bacterial Agents - therapeutic use; Bacteria - isolation & purification; Bile - microbiology; Cholecystectomy, Laparoscopic; Cholecystitis, Acute - microbiology; Cholecystitis, Acute - surgery; Cholecystostomy; Humans; Middle Aged; Pakistan; Retrospective Studies; Acute cholecystitis, Bile cultures, Bacteriobilia, Antibiotic susceptibility
• ISSN: 0030-9982

Acute cholecystitis is one of the most common acute surgical conditions. Laparoscopic cholecystectomy remains the mainstay of treatment. In patients managed non-operatively, antibiotics play an important role in the treatment of cholecystitis. The current retrospective observational study was conducted at a tertiary care hospital in Karachi, and comprised medical records of patients admitted between 2008 and 2014with acute cholecystitis and in whom bile cultures were obtained. Of the 509 patients with a mean age of 51.15 ± 13.4years, early laparoscopic cholecystectomy (within 72hours) was performed on 473(92.9%) cases, while the rest underwent percutaneous cholecystostomy. Bile cultureswere positive in 171(33.6%) patients. Predominantly gram-negative organisms were isolated among a total of 137(27%), with E.coli 63(46%) being the most commonly isolated organism. Of the gram-positive organism, enterococcus 11(8%) was the most common. Antibiotic sensitivities were determined.Based on our findings gram-negative coverage alone should be sufficient in our segment of the population.