A prospective observational study of 468 patients undergoing D2 or D3 lymphadenectomy for gastric cancer

• Published in: Hepato-gastroenterology Vol. 60; no. 123; p. 624
• Main Authors: Bostanci, Erdal Birol, Ozer, Ilter, Ercan, Metin, Ulas, Murat, Koc, Umit, Karaman, Kerem, Dalgic, Tahsin, Ozogul, Yusuf, Akoglu, Musa
• Format: Journal Article
• Language: English
• Published: Greece 01-05-2013
• Subjects: Adenocarcinoma - mortality; Adenocarcinoma - secondary; Adenocarcinoma - surgery; Adult; Aged; Chi-Square Distribution; Female; Gastrectomy - adverse effects; Gastrectomy - mortality; Humans; Kaplan-Meier Estimate; Lymph Node Excision - adverse effects; Lymph Node Excision - methods; Lymph Node Excision - mortality; Lymph Nodes - pathology; Lymph Nodes - surgery; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Prospective Studies; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Time Factors; Treatment Outcome
• ISSN: 0172-6390
• DOI: 10.5754/hge11507

A single-center, prospective observational study was performed to evaluate outcomes in patients undergoing D2 or D3 lymphadenectomy for gastric cancer.
Lymphadenectomies were performed according to the classification published by the Japanese Gastric Cancer Association.
Of 468 consecutive patients, 370 underwent D2 and 98 underwent D3 lymphadenectomy. Postoperative complications were significantly less common in the D2 group than in the D3 group (19.2% vs. 35.7%, p=0.001). Postoperative mortality in the two groups was similar, being 3.8% in the D2 group and 5.1% in the D3 group (p>0.05). Median postoperative survival times were also similar, in the D2 group being 37.8 months (95% CI: 23-52.5), and in the D3 group 30.2 months (95% CI: 13-47.3, p>0.05).
In patients who underwent gastrectomy with curative intent, lymphadenectomy that was more extensive than D2 did not provide a survival benefit compared to D2 dissection.