Update on Chemoreception: Influence on Cardiorespiratory Regulation and Pathophysiology

We examine recent findings that have revealed interdependence of function within the chemoreceptor pathway regulating breathing and sympathetic vasomotor activity and the hypersensitization of these reflexes in chronic disease states. Recommendations are made as to how these states of hyperreflexia...

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Bibliographic Details
Published in:	Clinics in chest medicine Vol. 40; no. 2; pp. 269 - 283
Main Authors:	Dempsey, Jerome A, Smith, Curtis A
Format:	Journal Article
Language:	English
Published:	United States 01-06-2019
Subjects:	Cardiorespiratory Fitness - physiology Chemoreceptor Cells - physiology Humans Sleep Apnea Syndromes - physiopathology Sensory hyperreflexia in chronic diseases Hypersensitization of chemoreception Carotid-medullary chemoreceptor interdependence
Online Access:	Get full text
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Summary:	We examine recent findings that have revealed interdependence of function within the chemoreceptor pathway regulating breathing and sympathetic vasomotor activity and the hypersensitization of these reflexes in chronic disease states. Recommendations are made as to how these states of hyperreflexia in chemoreceptors and muscle afferents might be modified in treating sleep apnea, drug-resistant hypertension, chronic heart failure-induced sympathoexcitation, and the exertional dyspnea of chronic obstructive pulmonary disease.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1557-8216
DOI:	10.1016/j.ccm.2019.02.001