A rare case of non-Hodgkins B-cell lymphoma in a psoriatic patient: a case report and literature review

Cyclosporine has been shown to increase the risk of lymphoma when used in organ transplant patients; however, studies have failed to demonstrate an increased risk of lymphoma when used at lower dermatologic doses for psoriasis. The authors present a case of solid B-cell lymphoma occurring in a psori...

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Bibliographic Details
Published in:	Journal of drugs in dermatology Vol. 9; no. 10; p. 1277
Main Authors:	Gattu, Shilpa, Becker, Emily M, Koo, John Y M
Format:	Journal Article
Language:	English
Published:	United States 01-10-2010
Subjects:	Adalimumab Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal, Humanized Cyclosporine - adverse effects Female Humans Immunosuppressive Agents - adverse effects Lymphoma, B-Cell - chemically induced Methotrexate - adverse effects Middle Aged Psoriasis - drug therapy
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Summary:	Cyclosporine has been shown to increase the risk of lymphoma when used in organ transplant patients; however, studies have failed to demonstrate an increased risk of lymphoma when used at lower dermatologic doses for psoriasis. The authors present a case of solid B-cell lymphoma occurring in a psoriasis patient with a history of intermittent exposure to high-dose methotrexate, followed by low-dose cyclosporine for two years and subsequently transitioned to treatment with adalimumab. Methotrexate, cyclosporine and adalimumab are each effective treatments for psoriasis. However, when faced with an interplay of several factors, closer surveillance for malignancy is warranted than that which is currently considered for monotherapy.
ISSN:	1545-9616