Wavelength-orthogonal photolysis of neurotransmitters in vitro

Irradiation of a mixture of 4-methoxyphenacyl-caged (S)-glutamate and 4,5-dimethoxy-2-nitrobenzyl-caged γ-amino butyric acid (GABA) on neurons, at ~260 nm, evokes selective photorelease of (S)-glutamate (Glu) whereas photolysis at 405 nm causes selective photorelease of GABA.

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Bibliographic Details
Published in:	Chemical communications (Cambridge, England) Vol. 48; no. 5; p. 657
Main Authors:	Stanton-Humphreys, Megan N, Taylor, Ruth D T, McDougall, Craig, Hart, Mike L, Brown, C Tom A, Emptage, Nigel J, Conway, Stuart J
Format:	Journal Article
Language:	English
Published:	England 18-01-2012
Subjects:	Animals Excitatory Amino Acid Antagonists - pharmacology GABA Antagonists - pharmacology gamma-Aminobutyric Acid - metabolism Glutamates - metabolism Hippocampus - cytology Hippocampus - drug effects Hippocampus - physiology Hippocampus - radiation effects Magnetic Resonance Spectroscopy Neurons - cytology Neurons - drug effects Neurons - physiology Neurons - radiation effects Neurotransmitter Agents - antagonists & inhibitors Neurotransmitter Agents - metabolism Patch-Clamp Techniques Photochemistry - methods Photolysis - radiation effects Receptors, GABA - metabolism Receptors, Glutamate - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology Synaptic Transmission - radiation effects Ultraviolet Rays
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Summary:	Irradiation of a mixture of 4-methoxyphenacyl-caged (S)-glutamate and 4,5-dimethoxy-2-nitrobenzyl-caged γ-amino butyric acid (GABA) on neurons, at ~260 nm, evokes selective photorelease of (S)-glutamate (Glu) whereas photolysis at 405 nm causes selective photorelease of GABA.
ISSN:	1364-548X
DOI:	10.1039/c1cc15135e