Breast and ovarian recurrence of acute lymphoblastic leukaemia after allogeneic peripheral blood haematopoietic stem cell transplantation

• Published in: Singapore medical journal Vol. 50; no. 12; p. e407
• Main Authors: Fadilah, S A W, Goh, K Y
• Format: Journal Article
• Language: English
• Published: Singapore 01-12-2009
• Subjects: Adolescent; Breast Neoplasms - complications; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - secondary; Female; Graft vs Host Disease - complications; Humans; Ovarian Neoplasms - complications; Ovarian Neoplasms - diagnostic imaging; Ovarian Neoplasms - secondary; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy; Tomography, X-Ray Computed
• ISSN: 0037-5675

Breast recurrence of acute lymphoblastic leukaemia (ALL) after stem cell transplant is uncommon, with less than 20 reported cases in the literature. In the majority of cases, the lesions developed without simultaneous involvement of other sites or graft-versus-host disease (GvHD). We describe the first case of simultaneous bilateral breast and ovarian relapses after allografting in ALL, occurring in an 18-year-old female Chinese patient while she was having oral and hepatic chronic GvHD, persistent haematological remission and donor haematopoiesis. She received radiotherapy and chemotherapy, which resulted in resolution of the breast and ovarian lesions, and remained disease free ten months after the onset of the relapse. This case suggests that there may be different mechanisms for bone marrow vs. extramedullary relapses and a complex relationship between GvHD and graft-versus-leukaemia.