Septic shock and community-acquired pneumonia associated with etanercept therapy

• Published in: International journal of clinical pharmacology and therapeutics Vol. 46; no. 4; p. 193
• Main Authors: Nuñez-Cornejo, C, Borrás-Blasco, J, Gracia-Perez, A, Rosique-Robles, J D, Lopez-Camps, V, Casterã, E, Abad, F J
• Format: Journal Article
• Language: English
• Published: Germany 01-04-2008
• Subjects: Aged; Antirheumatic Agents - therapeutic use; Arthritis, Psoriatic - drug therapy; Community-Acquired Infections - chemically induced; Community-Acquired Infections - microbiology; Etanercept; Female; Humans; Immunoglobulin G - adverse effects; Immunoglobulin G - therapeutic use; Pneumonia, Pneumococcal - chemically induced; Pneumonia, Pneumococcal - microbiology; Receptors, Tumor Necrosis Factor - therapeutic use; Respiratory Insufficiency - chemically induced; Shock, Septic - chemically induced; Streptococcus pneumoniae; Tumor Necrosis Factor-alpha - antagonists & inhibitors
• ISSN: 0946-1965
• DOI: 10.5414/cpp46193

To report a case of septic shock and community-acquired pneumonia in a patient with psoriatic arthritis receiving treatment with etanercept. PATIENT DETAILS: A 65-year-old woman diagnosed as having psoriatic arthritis had received treatment with etanercept. Chest X-ray studies were normal and the tuberculin skin test was negative. Two months after etanercept therapy, the patient presented to our emergency department with fever, cough, chest pain and generalized weakness. Chest radiography revealed a right pulmonary infiltrate. Her condition rapidly deteriorated and she went into shock with a further drop in her blood pressure, tachycardia and tachypnea. She was intubated, mechanically ventilated and was treated with fluids, cardioversion and amiodarone. Empiric therapy with levofloxacin, amikacin and cefepime were initiated. In the urinalysis, the result of a rapid test for Streptococcus pneumoniae was positive. Etanercept treatment was suspended due to a possible adverse reaction associated with this drug. At the start of therapy her clinical condition improved slowly. On Day 28, the patient was afebrile and she was discharged from the intensive care unit.
Most of the infections associated with etanercept therapy have been reported in patients with rheumatoid arthritis. Based on our observations, etanercept was the possible offender in the development of septic shock and respiratory failure in community-acquired pneumonia. There was a temporal relationship between exposure to the drug and onset of symptoms. Etanercept was the only drug administered before the septic shock developed. Based on the Naranjo algorithm, the adverse reaction could be considered possible.
Patients initiated on etanercept should be counseled and receive appropriate screening before drug initiation. All febrile and newly occurring concomitant illnesses should be promptly evaluated. General practitioners should discontinue etanercept treatment and institute prompt and aggressive intervention if infection develops.