Survival and prognostic factors of patients treated for Stage I to Stage III endometrial carcinoma in a reference cancer center in Southern Brazil

• Published in: European journal of gynaecological oncology Vol. 28; no. 1; p. 48
• Main Authors: Pessini, S A, Zettler, C G, Wender, M C O, Pellanda, L C, Silveira, G P G
• Format: Journal Article
• Language: English
• Published: Italy 2007
• Subjects: Adult; Aged; Aged, 80 and over; Brazil - epidemiology; Carcinoma, Endometrioid - mortality; Carcinoma, Endometrioid - pathology; Carcinoma, Endometrioid - surgery; Cohort Studies; Endometrial Neoplasms - mortality; Endometrial Neoplasms - pathology; Endometrial Neoplasms - surgery; Female; Humans; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Retrospective Studies; Survival Analysis; Treatment Outcome; Women's Health; Brazil
• ISSN: 0392-2936

To describe two- and five-year survival of patients with Stage I to III endometrial carcinoma and to identify prognostic factors.
Concurrent cohort study.
Seventy-two patients were operated on by the same surgeon and followed up for at least two years. All the histopathological examinations were performed by the same pathologist. Survival was analyzed by the Kaplan-Meier method. Age, body mass index, tumor grade, myometrial invasion, histological type and stage were correlated with death.
Overall survival at two and five years was 90.2% and 81.4%, respectively. By bivariate analysis, FIGO stage, myometrial invasion, tumor grade, histology, adnexal and/or lymph node metastasis and age were significant predictors of death (p < 0.05). Multivariate analysis revealed significant associations with death: FIGO Stage III (p = 0.001), histological type other than endometrioid (p = 0.027) and age 70 or more (p = 0.04).
Endometrial carcinoma Stage III patients, histological types other than endometrioid and age 70 years or more are at significant risk for death.