Novel seco-dibenzopyrrocoline alkaloid from Cryptocarya oubatchensis

[structure: see text] A novel seco-dibenzopyrrocoline alkaloid, named oubatchensine 6, and five phenanthroindolizidines (1-5) were isolated from Cryptocarya oubatchensis, and their structures were elucidated. Displacement centrifugal partition chromatography was used to purify compounds 1 and 6. Str...

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Bibliographic Details
Published in:	Organic letters Vol. 8; no. 17; pp. 3825 - 3828
Main Authors:	Toribio, Alix, Bonfils, Aurélie, Delannay, Eldra, Prost, Elise, Harakat, D, Henon, Eric, Richard, Bernard, Litaudon, Marc, Nuzillard, Jean-Marc, Renault, Jean-Hugues
Format:	Journal Article
Language:	English
Published:	United States 17-08-2006
Subjects:	Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Cryptocarya - chemistry Drug Screening Assays, Antitumor Heterocyclic Compounds, 4 or More Rings - chemistry Heterocyclic Compounds, 4 or More Rings - isolation & purification Heterocyclic Compounds, 4 or More Rings - pharmacology Humans KB Cells Molecular Conformation Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal - chemistry
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Summary:	[structure: see text] A novel seco-dibenzopyrrocoline alkaloid, named oubatchensine 6, and five phenanthroindolizidines (1-5) were isolated from Cryptocarya oubatchensis, and their structures were elucidated. Displacement centrifugal partition chromatography was used to purify compounds 1 and 6. Structure determination of the latter was carried out by mass spectrometry, NMR spectroscopy, quantum chemistry, and computer-assisted structure determination. Cytotoxic activity against KB cells was then investigated.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1523-7060
DOI:	10.1021/ol061435f