Touch imprint cytological diagnosis of nodal Langerhans cell histiocytosis

Touch imprint cytological diagnosis of nodal Langerhans cell histiocytosis. Langerhans cell histiocytosis (LCH) is a rare neoplasm of the mononuclear phagocytic immunoregulatory system of unknown aetiology. Nodal involvement is uncommon. Cytological findings have seldom been described. A case study...

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Bibliographic Details
Published in:	B-ENT (Leuven) Vol. 5; no. 2; p. 115
Main Authors:	Tamiolakis, D, Barbagadaki, S, Proimos, E, Nikolaidou, S, Chimona, T S, Georgiou, G, Perogamvrakis, G, Papadakis, C E
Format:	Journal Article
Language:	English
Published:	Belgium 2009
Subjects:	Adult Cytodiagnosis Female Histiocytosis, Langerhans-Cell - pathology Humans Lymph Nodes Mandible
Online Access:	Get more information
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Summary:	Touch imprint cytological diagnosis of nodal Langerhans cell histiocytosis. Langerhans cell histiocytosis (LCH) is a rare neoplasm of the mononuclear phagocytic immunoregulatory system of unknown aetiology. Nodal involvement is uncommon. Cytological findings have seldom been described. A case study of LCH, arising in a submandibular node of a 42-year-old female, is reported. Fine needle aspiration smears were highly cellular and composed of a mixed cell population including eosinophils, lymphocytes, neutrophils, and macrophages. Imprint slides from the surgical specimen of the excised node exhibited Langerhans cells with nuclear grooves, leading to a diagnosis suggestive of LCH. Immunohistochemical staining of the node sections with CD1a and S-100 confirmed this diagnosis. In conclusion, cytology may favorably contribute to the diagnosis of LCH.
ISSN:	1781-782X