Effect of therapy with atorvastatin on parameters of postprandial lipemia and factors of inflammation in patients with ischemic heart disease

• Published in: Kardiologiia Vol. 47; no. 2; p. 4
• Main Authors: Samoĭlenko, E Iu, Naumov, V G, Tvorogova, M G, Ezhov, M V, Sergienko, I V, Kukharchuk, V V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2007
• Subjects: Adult; Anticholesteremic Agents - pharmacology; Anticholesteremic Agents - therapeutic use; Atorvastatin Calcium; C-Reactive Protein - analysis; Female; Fibrinogen - analysis; Heptanoic Acids - pharmacology; Heptanoic Acids - therapeutic use; Humans; Hyperlipidemias - complications; Hyperlipidemias - drug therapy; Inflammation - complications; Inflammation - drug therapy; Lipids - blood; Male; Myocardial Ischemia - complications; Postprandial Period - drug effects; Pyrroles - pharmacology; Pyrroles - therapeutic use; Treatment Outcome
• ISSN: 0022-9040

Reaction of parameters of lipid transport system to standard fat load (J.Patsch method), C-reactive protein (CRP) and fibrinogen levels were studied in 30 patients with ischemic heart disease before and after 3 months of therapy with atorvastatin (10 mg/day). Atorvastatin therapy resulted in 25, 34, 17 and 16% lowering of concentrations of total cholesterol (CH), low density lipoprotein CH, triglycerides (TG), and apolipoprotein (apo) B, respectively, 6 and 9% elevation of high density lipoprotein CH and apo A-1 levels, respectively. Moreover atorvastatin improved although not completely normalized parameters of postprandial lipemia: significant lowering of baseline (-17%), 3 (-19%) and 6 hour (-14%) post load TG levels was noted. However relative TG elevation from baseline level to 3 and 6 hours after fat load did not change (+100 and 148% before, +95 and 156% after treatment, respectively). Changes of CRP (-22%) and fibrinogen (-8%) were not significant (p>0.05).