Human interferons alpha, beta and omega

Type I interferons (IFNs), IFN-alpha, IFN-beta, IFN-omega, IFN-delta and IFN-tau are a family of structurally related, species-specific proteins found only in vertebrates. They exhibit a variety of biological functions, including antiviral, antiproliferative, immunomodulatory and developmental activ...

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Bibliographic Details
Published in:	Growth factors (Chur, Switzerland) Vol. 22; no. 4; pp. 243 - 251
Main Authors:	Bekisz, Joseph, Schmeisser, Hana, Hernandez, Jessica, Goldman, Neil D, Zoon, Kathryn C
Format:	Journal Article
Language:	English
Published:	England 01-12-2004
Subjects:	Amino Acid Sequence Animals Humans Interferon Type I - physiology Interferon-alpha - physiology Interferon-alpha - therapeutic use Interferon-beta - physiology Interferon-beta - therapeutic use Models, Biological Models, Molecular Molecular Sequence Data Peptides - chemistry Protein Structure, Secondary Sequence Homology, Amino Acid Signal Transduction Structure-Activity Relationship
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Summary:	Type I interferons (IFNs), IFN-alpha, IFN-beta, IFN-omega, IFN-delta and IFN-tau are a family of structurally related, species-specific proteins found only in vertebrates. They exhibit a variety of biological functions, including antiviral, antiproliferative, immunomodulatory and developmental activities. Human Type I IFNs interact with the human IFN alpha receptor (IFNAR), which is composed of two identified subunits (IFNAR-1 and IFNAR-2). The interaction of IFN-alpha/beta with its receptor components results in the activation of a number of signaling pathways. The regulation of specific genes and proteins contributes to the numerous biological functions of Type I IFNs.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0897-7194
DOI:	10.1080/08977190400000833