Dermokine Expression in Intraductal Papillary-Mucinous Neoplasm and Invasive Pancreatic Carcinoma

• Published in: Anticancer research Vol. 32; no. 10; pp. 4405 - 4412
• Main Authors: WATANABE, Kenji, OOCHIAI, Toshiya, OTSUJI, Eigo, KIKUCHI, Shojiro, KUMANO, Tatsuya, MATSUI, Takeshi, MORIMOTO, Koji, YASUKAWA, Satoru, NAKAMORI, Shoji, SASAKO, Mitsuru, YANAGISAWA, Akio
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01-10-2012
• Subjects: Adenocarcinoma, Mucinous - metabolism; Adenocarcinoma, Mucinous - pathology; Biological and medical sciences; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; Carcinoma, Papillary - metabolism; Carcinoma, Papillary - pathology; Cell Line, Tumor; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Immunohistochemistry; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Proteins - metabolism; Tumors; Mucinous carcinoma; Serum marker; Biological marker; intraductal papillary mucinous neoplasm; Malignant tumor; dermokine; pancreatic cancer; Cancerology; Pancreas cancer; Digestive diseases; Serum; Invasive cancer; Cancer; Pancreatic disease; Pancreas carcinoma
• ISSN: 0250-7005; 1791-7530

Serum dermokine (DK) is a novel biomarker for early colorectal cancer. To our knowledge this is the first study of DK expression in intraductal papillary mucinous neoplasm (IPMN) and pancreatic cancer.
DK expression in human pancreatic cancer cell lines and tissues was assessed. We compared the sensitivities of common diagnostic markers, carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), s-pancreas-1 antigen (SPAN-1), pancreatic cancer-associated antigen (DUPAN-2), and Nation Cancer Center-Stomach-439 (NCC-ST-439) in 26 patients with pancreatic neoplasms.
DK was expressed in pancreatic cancer cell lines. Immunohistochemical staining revealed that DK was expressed in atypical and cancerous tissues, but not in the normal pancreatic tissues. Serum DK was relatively high in patients with IPMN. The sensitivities of a serum multimarker test including DK was 76.5% (n=13/17) for IPMA/IPMC/invasive carcinoma derived from IPMN, and 100% (n=9/9) for ordinary invasive ductal carcinoma.
Serum DK is a potential biomarker in IPMN and invasive ductal carcinoma, when used in combination with conventional biomarkers.