Pentylenetetrazole kindling induces caspase-3 activation in rat brain

Pentylenetetrazole kindling (but not a single pentylenetetrazole injection) induced caspase-3 activation in the cerebral cortex, hippocampus, and cerebellum of rats as well as neurodegeneration in the hippocampus. The number of neurons in the CA3 subfield of the hippocampus decreased significantly,...

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Bibliographic Details
Published in:	Zurnal vyss̆ej nervnoj dejatelnosti imeni I P Pavlova Vol. 53; no. 1; p. 110
Main Authors:	Pavlova, T V, Iakovlev, A A, Stepanichev, M Iu, Mendzheritskiĭ, A M, Guliaeva, N V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-2003
Subjects:	Animals Behavior, Animal - drug effects Caspase 3 Caspases - metabolism GABA Antagonists - administration & dosage GABA Antagonists - pharmacology Hippocampus - drug effects Hippocampus - enzymology Kindling, Neurologic - drug effects Male Pentylenetetrazole - administration & dosage Pentylenetetrazole - pharmacology Rats Rats, Wistar
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Summary:	Pentylenetetrazole kindling (but not a single pentylenetetrazole injection) induced caspase-3 activation in the cerebral cortex, hippocampus, and cerebellum of rats as well as neurodegeneration in the hippocampus. The number of neurons in the CA3 subfield of the hippocampus decreased significantly, whereas no apoptotic nuclei could be detected. The results support a possible non-apoptotic involvement of caspase-3 in brain plasticity.
ISSN:	0044-4677