Fibrogenesis. V. TGF-beta signaling pathways

Transforming growth factor (TGF)-beta is a multifunctional peptide growth factor with a wide range of potential effects on growth, differentiation, extracellular matrix deposition, and the immune response. General TGF-beta signaling pathways have been described in detail over the last several years,...

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Bibliographic Details
Published in:	American journal of physiology: Gastrointestinal and liver physiology Vol. 279; no. 5; p. G845
Main Author:	Wells, R G
Format:	Journal Article
Language:	English
Published:	United States 01-11-2000
Subjects:	Animals Humans Liver Cirrhosis - physiopathology Signal Transduction - physiology Transforming Growth Factor beta - physiology
Online Access:	Get more information
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Summary:	Transforming growth factor (TGF)-beta is a multifunctional peptide growth factor with a wide range of potential effects on growth, differentiation, extracellular matrix deposition, and the immune response. General TGF-beta signaling pathways have been described in detail over the last several years, but factors that determine the nature of the TGF-beta response are poorly understood. In particular, signaling pathways that specifically mediate the matrix effects of TGF-beta have received little attention, although they will be important therapeutic targets in the treatment of pathological fibrosis. This themes article focuses on TGF-beta signaling and highlights potential points for generating matrix-specific responses.
ISSN:	0193-1857
DOI:	10.1152/ajpgi.2000.279.5.g845