Subunit influenza vaccine and its testing in clinical immunology

Subunit adsorbed chemical influenza vaccine [ACI] was tested in subcutaneous administration by the needleless and syringe methods. A weak reactogenicity and a high immunogenic activity of the ACI vaccine was demonstrated after a single administration by the needleless and syringe methods [73.0---75....

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Bibliographic Details
Published in:	Journal of hygiene, epidemiology, microbiology, and immunology Vol. 24; no. 2; p. 212
Main Authors:	Zykov, M P, Rudenko, L G, Zoshchenkova, N Y, Rafael'skaya, T I
Format:	Journal Article
Language:	English
Published:	Czech Republic 1980
Subjects:	Adult Antibodies, Viral - biosynthesis Clinical Trials as Topic Humans Influenza A virus - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza Vaccines - immunology Vaccination
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Summary:	Subunit adsorbed chemical influenza vaccine [ACI] was tested in subcutaneous administration by the needleless and syringe methods. A weak reactogenicity and a high immunogenic activity of the ACI vaccine was demonstrated after a single administration by the needleless and syringe methods [73.0---75.0% of seroconversions with a geometric mean of the titre of 1:91.0---1:169.0 and a relative increase in antibody titre of 8.1---14.9]. Revaccination increased the mentioned indices to 75.0---86.0%, 1:128.0---1:181.0 and 11.3---16.0, respectively. A many-sided comparison of three preparations [ACI vaccine, "Vaxgrip" and "Mutagripe"] permitted to reveal a number of advantages in the Soviet vaccine. However, all the three preparations ensured an expressed protection against influenza virus.
ISSN:	0022-1732