Identification of transforming growth factor alpha in human primary breast carcinomas

Primary human mammary carcinomas were found to contain an acid stable polypeptide which bound to the receptor for epidermal growth factor (EGF). This polypeptide which was antigenetically different from EGF and thus identified as Tumor Growth Factor (TGF) alpha, could be identified in 25% of the tum...

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Bibliographic Details
Published in:	Anticancer research Vol. 7; no. 6; p. 1271
Main Authors:	Macias, A, Perez, R, Hägerström, T, Skoog, L
Format:	Journal Article
Language:	English
Published:	Greece 01-11-1987
Subjects:	Breast Neoplasms - analysis Chromatography, High Pressure Liquid Epidermal Growth Factor - analysis Female Humans Peptides - analysis Receptor, Epidermal Growth Factor - analysis Transforming Growth Factors
Online Access:	Get more information
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Summary:	Primary human mammary carcinomas were found to contain an acid stable polypeptide which bound to the receptor for epidermal growth factor (EGF). This polypeptide which was antigenetically different from EGF and thus identified as Tumor Growth Factor (TGF) alpha, could be identified in 25% of the tumors. Among these tumors 40% contained measurable levels of the EGF receptor. Thus these tumors exhibit the molecular prerequisite for autocrine growth stimulation.
ISSN:	0250-7005