Cytogenetic studies in ataxia telangiectasia & their use in prenatal diagnosis

Cytogenetic studies in ataxia telangiectasia & their use in prenatal diagnosis

Cytogenetic studies were carried out in obligate ataxia telangiectasia (AT) heterozygotes, AT homozygotes and control subjects. Rate of chromosomal aberrations and the frequency of micronuclei were examined before and after radiation (100 rads). Significant differences in the rate of chromosomal abe...

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Bibliographic Details
Published in:Indian journal of medical research (New Delhi, India : 1994) Vol. 103; p. 155
Main Authors: Chowdhury, M R, Singh, G, Shukla, A, Verma, I C
Format: Journal Article
Language:English
Published: India 01-03-1996
Subjects:
Ataxia Telangiectasia - genetics
Child
Chromosome Aberrations
Female
Humans
Micronuclei, Chromosome-Defective
Pregnancy
Prenatal Diagnosis
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Summary:Cytogenetic studies were carried out in obligate ataxia telangiectasia (AT) heterozygotes, AT homozygotes and control subjects. Rate of chromosomal aberrations and the frequency of micronuclei were examined before and after radiation (100 rads). Significant differences in the rate of chromosomal aberrations and micronuclei were observed among heterozygotes, homozygotes and controls. The same methods were then applied for prenatal diagnosis of AT using amniotic cell culture in two families.
ISSN:0971-5916