The effect of alpha-tocopherol and Intal on heart capillary bed and lipid peroxide oxidation in experimental necrosis of the rat myocardium

The effect of Intal and alpha-tocopherol on the morphofunctional state of myocardial capillary bed and peroxide oxidation of lipids (POL) was studied in 160 albino rats with coronary artery occlusion. The vascular effect of Intal consisted in increasing the number of functioning capillaries and enla...

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Bibliographic Details
Published in:	Cor et vasa (English ed.) Vol. 31; no. 6; p. 500
Main Authors:	Amatuni, V G, Matevosian, R S, Sisakian, S A, Arakelian, I G
Format:	Journal Article
Language:	English
Published:	Czech Republic 1989
Subjects:	Animals Capillaries - drug effects Coronary Circulation - drug effects Coronary Disease - drug therapy Coronary Disease - metabolism Coronary Disease - physiopathology Cromolyn Sodium - pharmacology Cromolyn Sodium - therapeutic use Heart - drug effects Lipid Peroxidation - drug effects Male Myocardium - metabolism Rats Vitamin E - pharmacology Vitamin E - therapeutic use
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Summary:	The effect of Intal and alpha-tocopherol on the morphofunctional state of myocardial capillary bed and peroxide oxidation of lipids (POL) was studied in 160 albino rats with coronary artery occlusion. The vascular effect of Intal consisted in increasing the number of functioning capillaries and enlargement of their exchange surface. alpha-tocopherol proved to be less effective in this respect. The authors assume that besides its influence on myocardial microcirculation through POL reduction, Intal supports the increase in the number of functioning capillaries.
ISSN:	0010-8650