Derivatives of 2-N-arylalkylamino-2-methyl-1-propanol with antiarrhythmic activity

Several aryl derivatives of achiral 2-amino-2-methyl-1-propanol have been obtained and tested for prophylactic and curative activity in different types of experimental arrhythmia. Interesting results were obtained for compounds 3 and 4 with activity and toxicity similar to those of quinidine.

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Bibliographic Details
Published in:	Polish journal of pharmacology and pharmacy Vol. 38; no. 2; p. 215
Main Authors:	Eckstein, M, Zajaczkowska, J, Krupińska, J, Michna, M
Format:	Journal Article
Language:	English
Published:	Poland 01-03-1986
Subjects:	Animals Anti-Arrhythmia Agents - chemical synthesis Anti-Arrhythmia Agents - toxicity Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - prevention & control Guinea Pigs Male Mice Propanolamines - chemical synthesis Propanolamines - pharmacology Propanolamines - toxicity Rats Rats, Inbred Strains
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Description
Summary:	Several aryl derivatives of achiral 2-amino-2-methyl-1-propanol have been obtained and tested for prophylactic and curative activity in different types of experimental arrhythmia. Interesting results were obtained for compounds 3 and 4 with activity and toxicity similar to those of quinidine.
ISSN:	0301-0244