Bioavailability of aspirin in the presence of dextropropoxyphene/paracetamol combination

The effect of 2 doses of a combination analgesic preparation (each dose containing 65 mg dextropropoxyphene hydrochloride and 650 mg paracetamol) upon plasma salicylate concentration after a single dose of soluble aspirin (1.2 g) or enteric-coated aspirin (1.2 g) was examined in 6 normal volunteers...

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Bibliographic Details
Published in:	Pharmatherapeutica Vol. 2; no. 8; p. 543
Main Authors:	Hemming, J D, Bird, H A, Pickup, M E, Saunders, A, Lowe, J R, Dixon, J S
Format:	Journal Article
Language:	English
Published:	England 1981
Subjects:	Acetaminophen - administration & dosage Acetaminophen - pharmacology Adolescent Adult Aspirin - metabolism Biological Availability Dextropropoxyphene - administration & dosage Dextropropoxyphene - pharmacology Drug Combinations - pharmacology Drug Interactions Female Humans Male
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Summary:	The effect of 2 doses of a combination analgesic preparation (each dose containing 65 mg dextropropoxyphene hydrochloride and 650 mg paracetamol) upon plasma salicylate concentration after a single dose of soluble aspirin (1.2 g) or enteric-coated aspirin (1.2 g) was examined in 6 normal volunteers and compared with the effect of placebo. The dextropropoxyphene/paracetamol caused no reduction in the plasma salicylate level after absorption of soluble aspirin compared with placebo and, although a reduction in plasma salicylate was seen after enteric-coated aspirin in a single subject, this may reflect erratic absorption rather than a drug interaction.
ISSN:	0308-051X