Hemodynamic response to exercise in the unanesthetized calf with pulseless arterial flow

In a chronic unanesthetized calf model with a centrifugal pump inserted from left ventricle to aorta, calves were trained to perform treadmill exercise and undergo hemodynamic measurements. Resting hemodynamic changes with pulseless pumping included increases in cardiac output, aortic pressure, and...

Full description

Saved in:

Bibliographic Details
Published in:	Transactions - American Society for Artificial Internal Organs Vol. 26; p. 1
Main Authors:	Shoor, P M, Hammill, F S, Griffith, L D, Dilley, R B, Bernstein, E F
Format:	Journal Article
Language:	English
Published:	United States 1980
Subjects:	Animals Assisted Circulation - instrumentation Assisted Circulation - methods Blood Pressure Cardiac Output Cattle Female Heart Rate Hemodynamics Physical Exertion
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	In a chronic unanesthetized calf model with a centrifugal pump inserted from left ventricle to aorta, calves were trained to perform treadmill exercise and undergo hemodynamic measurements. Resting hemodynamic changes with pulseless pumping included increases in cardiac output, aortic pressure, and heart rate, with some decrease in systemic vascular assistance. Treadmill exercise was associated with further increases in cardiac output and heart rate, which progressively increased during the 10 days of observation, with little change in mean aortic pressure. Pump autoregulation responded to the decreased systemic vascular resistance associated with exercise by increasing pump output about 15%, at constant pump rotatory speed. These experiments add further evidence regarding the ability of a centrifugal left ventricular assistance system to support the failing heart and to permit moderate degrees of exercise in the intact unanesthetized calf.
ISSN:	0066-0078