Pharmacokinetic evaluation of cimetidine in newborn infants

Pharmacokinetic evaluation of cimetidine in newborn infants

The pharmacokinetics of cimetidine were studied in three newborn infants with reflux esophagitis or stress ulcer. One infant was given 5 mg/kg intravenously (IV), one was given 10 mg/kg IV, and one was given 10 mg orally. Serum concentrations 30 minutes after administration were 1.2 micrograms/ml, 5...

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Bibliographic Details
Published in:Clinical therapeutics Vol. 7; no. 3; p. 361
Main Authors: Stile, I L, Simon, R, Hiatt, I M, Hegyi, T
Format: Journal Article
Language:English
Published: United States 1985
Subjects:
Cimetidine - metabolism
Half-Life
Humans
Infant
Infant, Newborn
Kinetics
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Summary:The pharmacokinetics of cimetidine were studied in three newborn infants with reflux esophagitis or stress ulcer. One infant was given 5 mg/kg intravenously (IV), one was given 10 mg/kg IV, and one was given 10 mg orally. Serum concentrations 30 minutes after administration were 1.2 micrograms/ml, 5 micrograms/ml, and 4.2 micrograms/ml, respectively. Concentrations greater than 0.5 micrograms/ml were measured 1, 6, and 9 hours, respectively, after administration. The half-life of the drug ranged from 1.10 to 2.18 hours. These preliminary data suggest that a dose of 5 to 7 mg/kg would effectively suppress gastric acid secretion in neonates.
ISSN:0149-2918