Rapid effects of dietary fish oil on peroxisomes in mouse liver

We investigated hepatic catalase activity, and morphologic and morphometric alterations of hepatocellular peroxisomes after catalase cytochemistry, in mice given a diet supplemented with 10% Beromegan, a commercial fish oil preparation, for up to three days. Fish oil is rich in docosahexaenoic acid...

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Bibliographic Details
Published in:	European journal of morphology Vol. 31; no. 1-2; p. 77
Main Authors:	De Craemer, D, Roels, F, Van den Branden, C
Format:	Journal Article
Language:	English
Published:	England 01-03-1993
Subjects:	Animals Catalase - analysis Dietary Fats - pharmacology Fish Oils - administration & dosage Fish Oils - pharmacology Liver - drug effects Liver - ultrastructure Male Mice Microbodies - drug effects Microbodies - enzymology Microbodies - ultrastructure Time Factors
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Summary:	We investigated hepatic catalase activity, and morphologic and morphometric alterations of hepatocellular peroxisomes after catalase cytochemistry, in mice given a diet supplemented with 10% Beromegan, a commercial fish oil preparation, for up to three days. Fish oil is rich in docosahexaenoic acid (C22:6 (n-3)) and in eicosapentaenoic acid (20:5 (n-3)). Hepatic catalase activity showed a gradual increase in mice fed this diet, being significantly increased (136 +/- 10 UB/g liver) after three days when compared top controls (85 +/- 11 UB/g liver). Light microscopy indicated an increase in peroxisomal staining and peroxisomal proliferation. The latter observation was confirmed by ultrastructural morphometry: number, volume density and surface density of the peroxisomes were more than doubled after a three day diet containing fish oil. Peroxisomal size was not changed. These alterations are suggestive for an increased peroxisomal metabolism induced by a diet rich in poly-unsaturated fatty acids.
ISSN:	0924-3860