Experimental radiotherapy and metastasis of human lung cancer xenografts in nude mice

Using a cell line derived from human lung cancer (AOI), we successfully established human xenografts in KSN nude mice, which showed high incidence of multiple spontaneous metastases. The highest incidence of metastasis in untreated hosts was observed in the spleen followed by the lungs and lymph nod...

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Bibliographic Details
Published in:	Chinese medical journal Vol. 107; no. 7; p. 491
Main Authors:	Zhang, J S, Nakatsugawa, S, Ishii, Y, Ju, G Z, Liu, S Z
Format:	Journal Article
Language:	English
Published:	China 01-07-1994
Subjects:	Animals Granulocyte-Macrophage Colony-Stimulating Factor - radiation effects Interleukin-1 - radiation effects Interleukin-6 - radiation effects Lung Neoplasms - pathology Lung Neoplasms - prevention & control Lung Neoplasms - radiotherapy Lung Neoplasms - secondary Lymphatic Metastasis Male Mice Mice, Nude Neoplasm Transplantation Splenic Neoplasms - prevention & control Splenic Neoplasms - secondary Tumor Cells, Cultured
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Summary:	Using a cell line derived from human lung cancer (AOI), we successfully established human xenografts in KSN nude mice, which showed high incidence of multiple spontaneous metastases. The highest incidence of metastasis in untreated hosts was observed in the spleen followed by the lungs and lymph nodes. The rate of metastasis reached 100% in the mice bearing large sized tumors, when metastasis to any organ or tissue was counted. Experimental radiotherapy caused remarkable redistribution of metastatic foci among different organs. Lung metastasis tended to decrease, while metastasis to the liver and the kidney was increased after radiotherapy. Radiation-induced production of cytokines was speculated to be responsible for such an alteration of metastasis pattern.
ISSN:	0366-6999