Acute toxicity studies of tri-n-butyltin and triphenyltin acetates in rats

Two organotin compounds, tri-n-butyltin acetate (TBTA) and triphenyltin acetate (TPTA), that have antifungal potentials and are intended for use on yam root crops to prevent rot were evaluated for acute mammalian toxicity in rats. The median lethal doses po were 297.54 mg TBTA/kg and 402.38 mg TPTA/...

Full description

Saved in:

Bibliographic Details
Published in:	Veterinary and human toxicology Vol. 33; no. 6; p. 554
Main Authors:	Attahiru, U S, Iyaniwura, T T, Adaudi, A O, Bonire, J J
Format:	Journal Article
Language:	English
Published:	United States 01-12-1991
Subjects:	Animals Dose-Response Relationship, Drug Female Fungicides, Industrial - administration & dosage Fungicides, Industrial - toxicity Gastrointestinal Diseases - chemically induced Gastrointestinal Diseases - pathology Lethal Dose 50 Male Organotin Compounds - administration & dosage Organotin Compounds - toxicity Rats Skin Diseases - chemically induced Skin Diseases - pathology Trialkyltin Compounds - administration & dosage Trialkyltin Compounds - toxicity
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Two organotin compounds, tri-n-butyltin acetate (TBTA) and triphenyltin acetate (TPTA), that have antifungal potentials and are intended for use on yam root crops to prevent rot were evaluated for acute mammalian toxicity in rats. The median lethal doses po were 297.54 mg TBTA/kg and 402.38 mg TPTA/kg. Both compounds produced significant central nervous system and respiratory depressions at single doses of 200 mg TBTA/kg or 300 mg TPTA/kg. The histopathological findings due to TBTA included pulmonary, hepatic and renal congestion, brain hemorrhages, and destruction of the intestinal mucosa. TPTA produced brain congestion, and hepatic and pulmonary petechial and generalized hemorrhages.
ISSN:	0145-6296