Time-dependent variation of HLA-antigen-frequencies in HIV-1-infection (1983-1988)

In a 5-year-study of HLA-phenotypes in 411 HIV-1-infected individuals, a progressive decrease of the formerly elevated frequency of HLA-DR5 has been observed. HLA-DR3 seems to have a protective effect. These results are discussed with respect to the mimicry-hypothesis of HLA and disease associations...

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Bibliographic Details
Published in:	Tissue antigens Vol. 34; no. 3; p. 164
Main Authors:	Kuntz, B M, Brüster, H T
Format:	Journal Article
Language:	English
Published:	England 01-09-1989
Subjects:	Acquired Immunodeficiency Syndrome - immunology Child Disease Susceptibility Female HIV-1 HLA Antigens - analysis HLA-B8 Antigen - analysis HLA-DR3 Antigen - analysis HLA-DR5 Antigen - analysis Humans Longitudinal Studies Male Phenotype
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Summary:	In a 5-year-study of HLA-phenotypes in 411 HIV-1-infected individuals, a progressive decrease of the formerly elevated frequency of HLA-DR5 has been observed. HLA-DR3 seems to have a protective effect. These results are discussed with respect to the mimicry-hypothesis of HLA and disease associations. Further preliminary results indicate that HIV-associated Kaposi's sarcoma could be associated with HLA-A28, and therefore might be a different etiologic entity than HIV-infection alone.
ISSN:	0001-2815
DOI:	10.1111/j.1399-0039.1989.tb01732.x