Comparison of FDG-PET/CT images between chronic renal failure patients on hemodialysis and controls

• Published in: American journal of nuclear medicine and molecular imaging Vol. 5; no. 2; pp. 204 - 211
• Main Authors: Toriihara, Akira, Kitazume, Yoshio, Nishida, Hidenori, Kubota, Kazunori, Nakadate, Masashi, Tateishi, Ukihide
• Format: Journal Article
• Language: English
• Published: United States e-Century Publishing Corporation 01-01-2015
• Subjects: Original; FDG-PET/CT; hemodialysis; physiological uptake; Chronic renal failure
• ISSN: 2160-8407; 2160-8407

The whole-body 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) distribution in chronic renal failure (CRF) patients on hemodialysis would be different from that in subjects with normal renal function, because they lack urinary FDG excretion and remain in a constant volume overload. We evaluated the difference in the physiological uptake pattern of FDG between chronic renal failure patients on hemodialysis and control subjects. The subjects for this retrospective study consisted of 24 chronic renal failure patients on hemodialysis (HD group) and 24 age- and sex-matched control subjects (NC group). Standardized uptake values normalized by the body weight (SUVbw), ideal body weight (SUVibw), lean body mass (SUVlbm), and body surface area (SUVbsa) in the cerebellum, lungs, liver, gluteal muscles and subcutaneous fat, spleen, thoracolumbar spine, thoracic and abdominal aorta, and right atrium were calculated in positron emission tomography/computed tomography (PET/CT) images. SUVbw in the gluteal muscles, subcutaneous fat, spleen and right atrium was significantly higher in the HD group as compared to that in the NC group (p < 0.05; unpaired t test). In addition, SUVibm, SUVlbm, as well as SUVbsa in the abdominal aorta were significantly higher in the HD group as compared to those in the NC group (p < 0.05; unpaired t test). In conclusion, as compared to normal subjects, chronic renal failure patients on hemodialysis show significantly higher physiological FDG uptake in the soft tissues, spleen and blood pool.