The Golgi Apparatus: Panel Point of Cytosolic Ca(2+) Regulation

• Published in: Neuro-Signals Vol. 21; no. 3-4; pp. 272 - 284
• Main Authors: Li, Li-Hua, Tian, Xiang-Rong, Jiang, Zheng, Zeng, Liu-Wang, He, Wen-Fang, Hu, Zhi-Ping
• Format: Journal Article
• Language: English
• Published: Switzerland 2013
• Subjects: Animals; Calcium - metabolism; Calcium Channels - physiology; Calcium Signaling - physiology; Calcium-Binding Proteins - metabolism; Cerebrovascular Disorders - metabolism; Cytosol - metabolism; Golgi Apparatus - physiology; Humans; Neurodegenerative Diseases - metabolism; Sarcoplasmic Reticulum Calcium-Transporting ATPases - physiology; Skin Diseases - metabolism
• ISSN: 1424-8638
• DOI: 10.1159/000350471

The Golgi apparatus (GA), an intermediate organelle of the cell inner membrane system, plays a key role in protein glycosylation and secretion. In recent years, this organelle has been found to act as a vital intracellular Ca(2+) store because different Ca (2+) regulators, such as the inositol-1,4,5-triphosphate receptor, sarco/endoplasmic reticulum Ca(2+) -ATPase and secretory pathway Ca 2+ -ATPase, were demonstrated to localize on their membrane. The mechanisms involved in Ca(2+) release and uptake in the GA have now been established.Here, based on careful backward looking on compartments and patterns in GA Ca (2+) regulation, we review neurological diseases related to GA calcium remodeling and propose a modified cytosolic Ca(2+) adjustment model, in which GA acts as part of the panel point.