Molecular mechanisms involved in epigenetic alterations in cancer

Epigenetic alterations such as DNA methylation and histone modification play a role in gene silencing in tumorigenesis. DNA methylation affects the expression of genes involved in cell cycle checkpoint, apoptosis, and DNA repair. Recently, epigenetic alterations are shown to play a role in silencing...

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Bibliographic Details
Published in:	Gan to kagaku ryoho Vol. 37; no. 9; p. 1650
Main Authors:	Toyota, Minoru, Suzuki, Hiromu, Nishizaka, Takahiro, Sato, Akiko, Yamashita, Toshiharu
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-09-2010
Subjects:	DNA Methylation Epigenesis, Genetic Gene Expression Regulation, Neoplastic Humans MicroRNAs - genetics Mutation Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism
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Summary:	Epigenetic alterations such as DNA methylation and histone modification play a role in gene silencing in tumorigenesis. DNA methylation affects the expression of genes involved in cell cycle checkpoint, apoptosis, and DNA repair. Recently, epigenetic alterations are shown to play a role in silencing microRNA. Mutations of DNA methyltransferase and histone modification enzymes such as DNMT3A, UTX and EZH2 have been shown in various types of tumors. Genes involved in epigenetic regulation may be novel targets of cancer therapy in the near future.
ISSN:	0385-0684