Osteoblast interaction with iron oxide nanoparticles coated with dextrin in cell culture

• Published in: Journal of Optoelectronics and Advanced Materials Vol. 10; no. 1; pp. 152 - 157
• Main Authors: Predoi, D, Vatasescu-Balcan, R A
• Format: Journal Article
• Language: English
• Published: 01-01-2008
• ISSN: 1454-4164

The iron oxide nanoparticles and iron oxide nanoparticles coated with dextrin have been synthesized using aqueous solution of ferric and ferrous ions and mixtures of dextrin with sodium salt. The size of the iron-oxide nanoparticles are controlled by the concentration of sodium salt in the medium. An average size of iron oxide and iron oxide coated with dextrin was found by transmission electron microscopie (TEM). The iron oxide nanoparticles are nearly spherical with an average diameter of about 8.0plus/minus 1 nm. The iron oxide nanoparticles coated with dextrin appear to cluster-like aggregates. The average diameter of these nanoparticles is about 6plus/minus 1 nm. The attachment of the dextrin on the particle surface was confirmed by FTIR spectroscopy and scanning electron microscopy (SEM). Osteoblasts used to determine the cell proliferation, viability and citotoxicity interaction with iron oxide nanoparticles coated with dextrin has been obtained from the upper part of the patient's femur.