Two additional cases of t dic(9:12) in acute lymphocytic leukemia (ALL): prognosis in ALL with dic(9:12)

We report two occurrences of dic(9;12) in acute lymphoblastic leukemia and review previous cases. Cases of dic(9;12) share common features with cases of 9p and 12p rearrangements, but prognosis seems particularly good in cases of dic(9;12). The persistence of a specific dicentric in stable clones is...

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Bibliographic Details
Published in:	Leukemia Vol. 4; no. 6; p. 423
Main Authors:	Huret, J L, Heerema, N A, Brizard, A, Provisor, A J, Benz-Lemoine, E, Guilhot, F, Savage, J R, Tanzer, J
Format:	Journal Article
Language:	English
Published:	England 01-06-1990
Subjects:	Adult Child, Preschool Chromosome Aberrations Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 9 Female Humans Karyotyping Male Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Prognosis Translocation, Genetic
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Summary:	We report two occurrences of dic(9;12) in acute lymphoblastic leukemia and review previous cases. Cases of dic(9;12) share common features with cases of 9p and 12p rearrangements, but prognosis seems particularly good in cases of dic(9;12). The persistence of a specific dicentric in stable clones is remarkable and points to unusual centromeric behavior and/or marked selective advantage of the anomaly.
ISSN:	0887-6924