cagA-positive Helicobacter pylori and risk for developing gastric carcinoma in Brazil

To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in...

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Published in:International journal of cancer Vol. 78; no. 2; pp. 135 - 139
Main Authors: QUEIROZ, D. M. M, MENDES, E. N, ROCHA, G. A, OLIVEIRA, A. M. R, OLIVEIRA, C. A, MAGALHAES, P. P, MOURA, S. B, CABRAL, M. M. D. A, NOGUEIRA, A. M. M. F
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Language:English
Published: New York, NY Wiley-Liss 05-10-1998
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Abstract To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in gastric biopsy specimens. A significant association was found between cag A-positive status and distal gastric carcinoma for both the intestinal and diffuse types of tumor for both males and females. On the other hand, no association was observed between cag A-positive status and proximal gastric carcinoma.
AbstractList To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in gastric biopsy specimens. A significant association was found between cag A-positive status and distal gastric carcinoma for both the intestinal and diffuse types of tumor for both males and females. On the other hand, no association was observed between cag A-positive status and proximal gastric carcinoma.
Author OLIVEIRA, C. A
MOURA, S. B
NOGUEIRA, A. M. M. F
MAGALHAES, P. P
MENDES, E. N
CABRAL, M. M. D. A
OLIVEIRA, A. M. R
QUEIROZ, D. M. M
ROCHA, G. A
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  surname: MENDES
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  givenname: M. M. D. A
  surname: CABRAL
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  organization: Department of Pathology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
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Issue 2
Keywords Human
Stomach
Carcinoma
Spirillales
Spirillaceae
Malignant tumor
Case control study
Epidemiology
Strain
Infection
Gene
Helicobacter pylori
Risk factor
Bacteriosis
Digestive diseases
Bacteria
Genetics
Public health
Gastric disease
Language English
License CC BY 4.0
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PublicationTitle International journal of cancer
PublicationTitleAlternate Int J Cancer
PublicationYear 1998
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Snippet To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter...
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StartPage 135
SubjectTerms Adult
Aged
Aged, 80 and over
Antigens, Bacterial
Bacterial Proteins - genetics
Biological and medical sciences
Case-Control Studies
Cross-Sectional Studies
Female
Gastroenterology. Liver. Pancreas. Abdomen
Genes, Bacterial
Helicobacter Infections - complications
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - genetics
Humans
Male
Medical sciences
Middle Aged
Polymerase Chain Reaction
Prospective Studies
Risk Factors
Sensitivity and Specificity
Stomach Neoplasms - microbiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Title cagA-positive Helicobacter pylori and risk for developing gastric carcinoma in Brazil
URI https://www.ncbi.nlm.nih.gov/pubmed/9754640
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Volume 78
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