cagA-positive Helicobacter pylori and risk for developing gastric carcinoma in Brazil
To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in...
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Published in: | International journal of cancer Vol. 78; no. 2; pp. 135 - 139 |
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Main Authors: | , , , , , , , , |
Format: | Journal Article |
Language: | English |
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Wiley-Liss
05-10-1998
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Abstract | To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in gastric biopsy specimens. A significant association was found between cag A-positive status and distal gastric carcinoma for both the intestinal and diffuse types of tumor for both males and females. On the other hand, no association was observed between cag A-positive status and proximal gastric carcinoma. |
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AbstractList | To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in gastric biopsy specimens. A significant association was found between cag A-positive status and distal gastric carcinoma for both the intestinal and diffuse types of tumor for both males and females. On the other hand, no association was observed between cag A-positive status and proximal gastric carcinoma. |
Author | OLIVEIRA, C. A MOURA, S. B NOGUEIRA, A. M. M. F MAGALHAES, P. P MENDES, E. N CABRAL, M. M. D. A OLIVEIRA, A. M. R QUEIROZ, D. M. M ROCHA, G. A |
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Keywords | Human Stomach Carcinoma Spirillales Spirillaceae Malignant tumor Case control study Epidemiology Strain Infection Gene Helicobacter pylori Risk factor Bacteriosis Digestive diseases Bacteria Genetics Public health Gastric disease |
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SubjectTerms | Adult Aged Aged, 80 and over Antigens, Bacterial Bacterial Proteins - genetics Biological and medical sciences Case-Control Studies Cross-Sectional Studies Female Gastroenterology. Liver. Pancreas. Abdomen Genes, Bacterial Helicobacter Infections - complications Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - genetics Humans Male Medical sciences Middle Aged Polymerase Chain Reaction Prospective Studies Risk Factors Sensitivity and Specificity Stomach Neoplasms - microbiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
Title | cagA-positive Helicobacter pylori and risk for developing gastric carcinoma in Brazil |
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