cagA-positive Helicobacter pylori and risk for developing gastric carcinoma in Brazil

• Published in: International journal of cancer Vol. 78; no. 2; pp. 135 - 139
• Main Authors: QUEIROZ, D. M. M, MENDES, E. N, ROCHA, G. A, OLIVEIRA, A. M. R, OLIVEIRA, C. A, MAGALHAES, P. P, MOURA, S. B, CABRAL, M. M. D. A, NOGUEIRA, A. M. M. F
• Format: Journal Article
• Language: English
• Published: New York, NY Wiley-Liss 05-10-1998
• Subjects: Adult; Aged; Aged, 80 and over; Antigens, Bacterial; Bacterial Proteins - genetics; Biological and medical sciences; Case-Control Studies; Cross-Sectional Studies; Female; Gastroenterology. Liver. Pancreas. Abdomen; Genes, Bacterial; Helicobacter Infections - complications; Helicobacter Infections - microbiology; Helicobacter pylori; Helicobacter pylori - genetics; Humans; Male; Medical sciences; Middle Aged; Polymerase Chain Reaction; Prospective Studies; Risk Factors; Sensitivity and Specificity; Stomach Neoplasms - microbiology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; South America; Brazil; America; Human; Stomach; Carcinoma; Spirillales; Spirillaceae; Malignant tumor; Case control study; Epidemiology; Strain; Infection; Gene; Helicobacter pylori; Risk factor; Bacteriosis; Digestive diseases; Bacteria; Genetics; Public health; Gastric disease
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/(sici)1097-0215(19981005)78:2<135::aid-ijc1>3.0.co;2-%23

To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in gastric biopsy specimens. A significant association was found between cag A-positive status and distal gastric carcinoma for both the intestinal and diffuse types of tumor for both males and females. On the other hand, no association was observed between cag A-positive status and proximal gastric carcinoma.