Signaling Pathways That Control the Growth and Survival of Prostate Carcinoma Cells in the Absence of Androgens

Signaling Pathways That Control the Growth and Survival of Prostate Carcinoma Cells in the Absence of Androgens

Androgen-dependent human prostate adenocarcinoma cell line LNCaP was used to study the effect of androgen deprivation on the cell response to TNF-related cytokines. Several signaling pathways were implicated in cell survival in the absence of androgens. In androgen-deprived LNCaP cells, TNF-α and TR...

Full description

Saved in:
Bibliographic Details
Published in:Molecular biology (New York) Vol. 37; no. 4; p. 585
Main Authors: Adler, V V, Polotskaya, A V, Gershtein, E S, Krasil'nikov, M A
Format: Journal Article
Language:English
Published: New York Springer Nature B.V 01-07-2003
Subjects:
Androgens
Cells
Proteins
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Androgen-dependent human prostate adenocarcinoma cell line LNCaP was used to study the effect of androgen deprivation on the cell response to TNF-related cytokines. Several signaling pathways were implicated in cell survival in the absence of androgens. In androgen-deprived LNCaP cells, TNF-α and TRAIL stimulated the cell growth and activated the mitogenic and antiapoptotic signaling pathways involving NF-κB, STAT3, PI3K, and β-catenin. The results suggested a role of cytokines in the survival of prostate adenocarcinoma cells deprived of androgens in vitro.[PUBLICATION ABSTRACT]
ISSN:0026-8933
1608-3245
DOI:10.1023/A:1025143528771