Multiple lipomatosis after stem cell trasplant and chemotherapy: a case report

• Published in: European review for medical and pharmacological sciences Vol. 18; no. 3; p. 413
• Main Authors: Bracaglia, R, D'Ettorre, M, Gentileschi, S, Mingrone, G, Tambasco, D
• Format: Journal Article
• Language: English
• Published: Italy 2014
• Subjects: Adult; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Humans; Lipoma - etiology; Lipoma - pathology; Lipoma - surgery; Male; Neoplasms, Germ Cell and Embryonal - drug therapy; Neoplasms, Germ Cell and Embryonal - therapy; Peripheral Blood Stem Cell Transplantation - adverse effects; Testicular Neoplasms - therapy
• ISSN: 2284-0729

Lipomas are the most common type of soft tissue benign tumor. They can be either isolated entities or involved in a multiple lipomatosis, which may have a familial basis or be an acquired condition.
Chemotherapy and/or blood stem cell transplantation may be plausible causes of multiple lipomatosis.
A 28 year-old patient was diagnosed with non-seminomatous germ cell left testicular cancer. The patient was addressed to chemotherapy and peripheral blood stem cell chemomobilization. After stem cells collection, the patient underwent autologous peripheral blood stem cell transplant.
A subsequent de novo multiple lipomatosis onset developed.
Although this is a preliminary study and further elaborations are needed, dermatologists and surgeons facing with multiple lipomatosis should consider previous chemotherapy and peripheral blood stem cell mobilization/transplant as possible causes of its onset.