Antioxidative effects of alpha-lipoic acid in spinal cord injury An experimental rat model

Traumatic and ischemic injuries of the spinal cord are effective in the development of neurological dysfunction of tissue damage caused by primary and secondary mechanisms. Free radical changes are effective in the development of early ischemia and progressive tissue ischemia is the main cause of se...

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Bibliographic Details
Published in:	Annali italiani di chirurgia Vol. 92; p. 98
Main Authors:	Ercan, Serdar, Aktas, Ayfer, Kemaloglu, Mustafa Serdar
Format:	Journal Article
Language:	English
Published:	Italy 01-01-2021
Subjects:	Animals Antioxidants - pharmacology Antioxidants - therapeutic use Disease Models, Animal Methylprednisolone - pharmacology Rats Rats, Sprague-Dawley Rats, Wistar Spinal Cord Injuries - complications Spinal Cord Injuries - drug therapy Thioctic Acid - pharmacology Thioctic Acid - therapeutic use
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Summary:	Traumatic and ischemic injuries of the spinal cord are effective in the development of neurological dysfunction of tissue damage caused by primary and secondary mechanisms. Free radical changes are effective in the development of early ischemia and progressive tissue ischemia is the main cause of secondary damage. Delaying ischemia is the basis of treatment. In this study, we aimed to demonstrate the presence of neuroprotective effects of alpha-lipoic acid in comparison with methylprednisolone. 50 Sprague Dawley rats were divided into 5 groups (n = 10) and spinal cord trauma was created by the method, described by Rivlin and Tator. Group 1: Laminectomy group, Group 2: Laminectomy + spinal cord injury (SCI), Group 3: Laminectomy + SCI + alpha-lipoic acid (ALA) (100 mg / kg), Group 4: Laminectomy + SCl + Methyl-prednisolone (30 mg / kg), Group 5: Laminectomy + SCl + ALA + Methyl-prednisolone. Rats with spinal cord injury were found to be paraplegic. There was no significant change in motor function between the groups. When the antioxidant values were compared in the groups, there was a statistically significant difference between Group 2 and Group 3. Oxygen radicals decreased significantly between ALA and Methylprednisolone. The most striking difference was between the monotherapy group and the combined treatment group. Our results showed that alpha lipoic acid given after spinal cord trauma in rats decreases anti-oxidant formation. Alpha-lipoic acid, Methyl-prednisolone, Oxygen radicals, Spinal cord injury.
ISSN:	2239-253X