Biological study of alcohol dependence syndrome with reference to ethnic difference: report of a WHO Collaborative Study

Inherited deficiency of acetaldehyde dehydrogenase type I (ALDH-I) was found in 43% (50/117) of normals, 33% (27/82) of schizophrenics, but only 4% (5/113) of alcoholics among Japanese. The ALDH-I deficiency was never found, however, in 146 mostly schizophrenic subjects from Europe (Basel, Moscow, Z...

Full description

Saved in:

Bibliographic Details
Published in:	Japanese journal of psychiatry and neurology Vol. 44; no. 1; p. 79
Main Authors:	Yamashita, I, Ohmori, T, Koyama, T, Mori, H, Boyadjive, S, Kielholz, P, Gastpar, M, Moussaoui, D, Bouzekraoui, M, Sethi, B B
Format:	Journal Article
Language:	English
Published:	Japan 01-03-1990
Subjects:	Alcoholism - enzymology Alcoholism - ethnology Aldehyde Oxidoreductases - deficiency Ethanol - metabolism Europe - ethnology Female Humans Japan Male Mexico - ethnology Philippines - ethnology Schizophrenia - enzymology Schizophrenia - ethnology World Health Organization Mexico Europe Japan Philippines
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Inherited deficiency of acetaldehyde dehydrogenase type I (ALDH-I) was found in 43% (50/117) of normals, 33% (27/82) of schizophrenics, but only 4% (5/113) of alcoholics among Japanese. The ALDH-I deficiency was never found, however, in 146 mostly schizophrenic subjects from Europe (Basel, Moscow, Zagreb), Australia (Nedlands), India (Lucknow), Morocco (Casablanca) and Mexico (Mexico City). It was demonstrated that ALDH-I deficiency produces the flushing syndrome which inhibits the development of drinking habit and alcohol dependence syndrome.
ISSN:	0912-2036