Structures of paralytic acylpolyamines from the spider Agelenopsis aperta

The structures are given for five paralytic acylpolyamines from the venom of the funnel web spider, Agelenopsis aperta. The acyl moieties are derived from (3-indolyl)acetic acid, (4-hydroxy-3-indolyl)acetic acid, and 4-hydroxybenzoic acid. The polyamine portions of the toxins are novel. Three toxins...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 169; no. 1; p. 51
Main Authors:	Quistad, G B, Suwanrumpha, S, Jarema, M A, Shapiro, M J, Skinner, W S, Jamieson, G C, Lui, A, Fu, E W
Format:	Journal Article
Language:	English
Published:	United States 31-05-1990
Subjects:	Animals Arthropod Venoms - analysis Hydroxylamines - analysis Hydroxylamines - toxicity Magnetic Resonance Spectroscopy Mass Spectrometry Paralysis - chemically induced Polyamines - analysis Polyamines - toxicity Spider Venoms - analysis Spider Venoms - toxicity
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Summary:	The structures are given for five paralytic acylpolyamines from the venom of the funnel web spider, Agelenopsis aperta. The acyl moieties are derived from (3-indolyl)acetic acid, (4-hydroxy-3-indolyl)acetic acid, and 4-hydroxybenzoic acid. The polyamine portions of the toxins are novel. Three toxins (AG489, AG505, and AG452) contain 1, 5, 9, 13, 18, 22-hexaazadocosane which is unique as a natural polyamine because of its length and hydroxylation at the 5-aza position. The polyamine portions of two other alpha-agatoxins (AG488 and AG504) are unusual also, containing guanidinooxy moieties.
ISSN:	0006-291X
DOI:	10.1016/0006-291X(90)91431-Q