Circulatory and Ventilatory Power: Characterization in Patients with Coronary Artery Disease

• Published in: Arquivos brasileiros de cardiologia Vol. 104; no. 6; pp. 476 - 485
• Main Authors: Castello-Simões, Viviane, Minatel, Vinicius, Karsten, Marlus, Simões, Rodrigo Polaquini, Perseguini, Natália Maria, Milan, Juliana Cristina, Arena, Ross, Neves, Laura Maria Tomazi, Borghi-Silva, Audrey, Catai, Aparecida Maria
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Cardiologia 01-06-2015
• Subjects: Adult; Aged; Blood Pressure - physiology; Carbon Dioxide - metabolism; Case-Control Studies; Coronary Artery Disease - physiopathology; Cross-Sectional Studies; Exercise - physiology; Exercise Test; Exercise Tolerance - physiology; Heart Rate - physiology; Humans; Male; Middle Aged; Original; Oxygen Consumption - physiology; Reference Values; Respiratory Function Tests; Statistics, Nonparametric; Time Factors
• ISSN: 0066-782X; 1678-4170
• DOI: 10.5935/abc.20150035

Circulatory power (CP) and ventilatory power (VP) are indices that have been used for the clinical evaluation of patients with heart failure; however, no study has evaluated these indices in patients with coronary artery disease (CAD) without heart failure.
To characterize both indices in patients with CAD compared with healthy controls.
Eighty-seven men [CAD group = 42 subjects and healthy control group (CG) = 45 subjects] aged 40-65 years were included. Cardiopulmonary exercise testing was performed on a treadmill and the following parameters were measured: 1) peak oxygen consumption (VO2), 2) peak heart rate (HR), 3) peak blood pressure (BP), 4) peak rate-pressure product (peak systolic HR x peak BP), 5) peak oxygen pulse (peak VO2/peak HR), 6) oxygen uptake efficiency (OUES), 7) carbon dioxide production efficiency (minute ventilation/carbon dioxide production slope), 8) CP (peak VO2 x peak systolic BP) and 9) VP (peak systolic BP/carbon dioxide production efficiency).
The CAD group had significantly lower values for peak VO2 (p < 0.001), peak HR (p < 0.001), peak systolic BP (p < 0.001), peak rate-pressure product (p < 0.001), peak oxygen pulse (p = 0.008), OUES (p < 0.001), CP (p < 0.001), and VP (p < 0.001) and significantly higher values for peak diastolic BP (p = 0.004) and carbon dioxide production efficiency (p < 0.001) compared with CG. Stepwise regression analysis showed that CP was influenced by group (R2 = 0.44, p < 0.001) and VP was influenced by both group and number of vessels with stenosis after treatment (interaction effects: R2 = 0.46, p < 0.001).
The indices CP and VP were lower in men with CAD than healthy controls.