Signal Transduction through the CD4 Receptor Involves the Activation of the Internal Membrane Tyrosine-Protein Kinase p56(lck)

Signal Transduction through the CD4 Receptor Involves the Activation of the Internal Membrane Tyrosine-Protein Kinase p56(lck)

Evidence that cross-linking of the CD4 receptor induces a rapid increase in the tyrosine-specific protein kinase activity of p56lck, and is associated with the rapid phosphorylation of one of the subunits of the T-cell receptor complex on tyrosine residues, is presented.

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Bibliographic Details
Published in:Nature (London) Vol. 338; no. 6212; p. 257
Main Authors: Veillette, Andre, Bookman, Michael A, Horak, Eva M, Samelson, Lawrence E, Bolen, Joseph B
Format: Journal Article
Language:English
Published: London Nature Publishing Group 16-03-1989
Subjects:
Biochemistry
Enzymes
Proteins
Online Access:Get full text
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Description
Summary:Evidence that cross-linking of the CD4 receptor induces a rapid increase in the tyrosine-specific protein kinase activity of p56lck, and is associated with the rapid phosphorylation of one of the subunits of the T-cell receptor complex on tyrosine residues, is presented.
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ISSN:0028-0836
1476-4687
DOI:10.1038/338257a0